Neuroprotective Effect of L-carnitine. Focus on Changing Mitochondrial Function

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Effect of L-carnitine on cardiac hemodynamics.

The effect of L-carnitine on cardiac hemodynamics was evaluated in normal closed chest dogs. Extracorporeal circulation was produced to measure coronary blood flow in closed chest dogs. Coronary venous blood was introduced to the extracorporeal circuit through a polyethylene catheter wedged into the coronary sinus under fluoroscopic control and was returned to the animal through the jugular vei...

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Neuroprotective Effects of Pre-Treament with l-Carnitine and Acetyl-l-Carnitine on Ischemic Injury In Vivo and In Vitro

The therapeutic effect of stroke is hampered by the lack of neuroprotective drugs against ischemic insults beyond the acute phase. Carnitine plays important roles in mitochondrial metabolism and in modulating the ratio of coenzyme A (CoA)/acyl-CoA. Here, we investigate the neuroprotective effects of l-carnitine (LC) and Acetyl-l-carnitine (ALC) pre-treatment on ischemic insults under the same e...

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The Effect of Aerobic Training and L- Carnitine on BCL2 and Mitochondrial Enzymes of Rat\'s Kidney

Objective: Diabetes causes free radical production, oxidative stress and alterations in mitochondrial enzymes and apoptosis. The purpose of this study was to investigate the effect of aerobic exercise and consumption of L-carnitine on BCL2 and some mitochondrial enzymes of the kidney in diabetic rats. Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were simp...

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Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes.

Although mitochondrial oxidative catabolism of fatty acid (FA) is a major energy source for the adult mammalian heart, cardiac lipotoxity resulting from elevated serum FA and enhanced FA use has been implicated in the pathogenesis of heart failure. To investigate the effects of intermediates of FA metabolism [palmitoyl-l-carnitine (Pal-car) and palmitoyl-CoA (Pal-CoA)] on mitochondrial function...

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ژورنال

عنوان ژورنال: Research Results in Pharmacology

سال: 2020

ISSN: 2658-381X

DOI: 10.3897/rrpharmacology.6.57419